Article
Mechanistic insights into folate supplementation from Crooked tail and other NTD-prone mutant mice.
Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2009
Gray Jason D, Ross M Elizabeth
Abstract excerpt
Despite two decades of research since Smithells and colleagues began exploring its benefits, the mechanisms through which folic acid supplementation supports neural tube closure and early embryonic development are still unclear. The greatest progress toward a molecular-genetic understanding of folate effects on neural tube defect (NTD) pathogenesis has come from animal models. The number of NTD-associated mouse...
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