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Article

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.

Development (Cambridge, England) - 1 Jun 2004

Kelly Olivia G, Pinson Kathy I, Skarnes William C

Abstract excerpt

Recent work has identified LDL receptor-related family members, Lrp5 and Lrp6, as co-receptors for the transduction of Wnt signals. Our analysis of mice carrying mutations in both Lrp5 and Lrp6 demonstrates that the functions of these genes are redundant and are essential for gastrulation. Lrp5;Lrp6 double homozygous mutants fail to establish a primitive streak, although the anterior visceral endoderm and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Low Density Lipoprotein Receptor-Related Protein-5

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Source

Identifiers

PMID: 15142971
DOI: 10.1242/dev.01137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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