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Article

Genetic interaction between Lrp6 and Wnt5a during mouse development.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2010

Andersson Emma R, Bryjova Lenka, Biris Kristin, Yamaguchi Terry P, Arenas Ernest, Bryja Vítezslav

Abstract excerpt

Lrp6 is generally described as a receptor required for signal transduction in the Wnt/beta-catenin pathway. Wnt5a, however, is a Wnt ligand that usually does not activate Wnt/beta-catenin but rather activates noncanonical Wnt signaling. We have previously shown that Lrp6 can inhibit noncanonical Wnt5a/Wnt11 signaling and that Lrp5/6 loss-of-function produces noncanonical gain-of function defects, which can be...

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Source

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Identifiers

PMID: 19795512
DOI: 10.1002/dvdy.22101
PMCID: PMC7282147

Genes

LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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