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Article

Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2013

Momb Jessica, Lewandowski Jordan P, Bryant Joshua D, Fitch Rebecca, Surman Deborah R, Vokes Steven A, Appling Dean R

Abstract excerpt

Maternal supplementation with folic acid is known to reduce the incidence of neural tube defects (NTDs) by as much as 70%. Despite the strong clinical link between folate and NTDs, the biochemical mechanisms through which folic acid acts during neural tube development remain undefined. The Mthfd1l gene encodes a mitochondrial monofunctional 10-formyl-tetrahydrofolate synthetase, termed MTHFD1L. This gene is...

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Identifiers

PMID: 23267094
DOI: 10.1073/pnas.1211199110
PMCID: PMC3545794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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