Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid.

Birth defects research - 17 Jul 2018

Gao Xiaoya, Finnell Richard H, Wang Hongyan, Zheng Yufang

Abstract excerpt

BACKGROUND: Neural tube defects (NTDs) are clinically significant congenital malformations which are known to be folic acid (FA) responsive, such that supplementation significantly reduces the prevalence of NTDs. Nonetheless, some individuals fail to respond to FA supplementation; hence NTDs remain a significant public health concern. The mechanisms that underlie the beneficial effects of FA supplementation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folic Acid
Share to Gene Expression Profiling
Share to Gene Ontology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Metabolic Networks and Pathways

Share to Mutation

Share to Neural Tube Defects

Source

Open in PubMed Open full text

Identifiers

PMID: 29732722
DOI: 10.1002/bdr2.1336
PMCID: PMC6320695

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid.PMID 29732722Read ↗

Mechanistic insights into folate supplementation from Crooked tail and other NTD-prone mutant mice.Semantic proximity Read ↗

Unraveling the complex genetics of neural tube defects: From biological models to human genomics and back.Semantic proximity Read ↗

A quest for genetic causes underlying signaling pathways associated with neural tube defectsSemantic proximity Read ↗

Investigations into the etiology of neural tube defectsSemantic proximity Read ↗

Finding the genetic mechanisms of folate deficiency and neural tube defects—Leaving no stone unturnedSemantic proximity Read ↗

Abnormal methylation caused by folic acid deficiency in neural tube defectsSemantic proximity Read ↗

Neural Tube Defects, Folic Acid and MethylationSemantic proximity Read ↗

Micronutrient imbalance and common phenotypes in neural tube defectsSemantic proximity Read ↗

Association between rare variants in specific functional pathways and human neural tube defects multiple subphenotypes.Semantic proximity Read ↗

Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival.Semantic proximity Read ↗

Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression.Semantic proximity Read ↗

Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.