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Article

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2005

Carter Michelle, Chen Xu, Slowinska Bozena, Minnerath Sharon, Glickstein Sara, Shi Lei, Campagne Fabien, Weinstein Harel, Ross M Elizabeth

Abstract excerpt

A cranial neural tube defect in Crooked tail (Cd) mice is prevented with prenatal dietary folic acid Cd positional cloning reveals a missense mutation of a highly conserved amino acid in the low density lipoprotein receptor-related protein 6 (Lrp6), a coreceptor required for Wnt canonical signaling. Molecular modeling predicts that Lrp6(Cd) alters a hinge region of the second YWTD beta-propeller domain. Mutant...

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Source

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Identifiers

PMID: 16126904
DOI: 10.1073/pnas.0501963102
PMCID: PMC1200260

Genes

LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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