Article

Canonical Wnt pathway modulation is required to correctly execute multiple independent cellular dynamic programs during cranial neural tube closure

2024-12-20

Abstract excerpt

Defects in cranial neural tube closure are among the most common and deleterious human structural birth defects. Correct cranial closure requires the coordination of multiple cell dynamic programs including cell proliferation and cell shape change. Mutations that impact Wnt signaling, including loss of the pathway co-receptor LRP6, lead to defects in cranial neural tube closure, but the cellular dynamics under con...

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Literature Corpus work: 5354f4f9-7ec7-57f8-b75a-d60a787b8428
DOI: 10.1101/2024.12.19.629501

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