Article

Variation in<i>ERAP2</i>has opposing effects on severe respiratory infection and autoimmune disease

2022-11-05

Abstract excerpt

<h4>Introduction</h4> ERAP2 is an aminopeptidase involved in immunological antigen presentation. Genotype data in human samples from before and after the Black Death, an epidemic due to Yersinia pestis , have marked changes in population allele frequency of the common single nucleotide polymorphism (SNP) rs2549794. This SNP in strong linkage disequilibrium with a key splicing SNP in ERAP2 (rs2248374) and this sugg...

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Literature Corpus work: 52863121-4ada-5016-a75d-83152ead88e5
DOI: 10.1101/2022.11.04.22281942

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