Article
Polyamine pathway contributes to the pathogenesis of Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2010
Lewandowski Nicole M, Ju Shulin, Verbitsky Miguel, Ross Barbara, Geddie Melissa L, Rockenstein Edward, Adame Anthony, Muhammad Alim, Vonsattel Jean Paul, Ringe Dagmar, Cote Lucien, Lindquist Susan, Masliah Eliezer, Petsko Gregory A, Marder Karen, Clark Lorraine N, Small Scott A
Abstract excerpt
The full complement of molecular pathways contributing to the pathogenesis of Parkinson disease (PD) remains unknown. Here we address this issue by taking a broad approach, beginning by using functional MRI to identify brainstem regions differentially affected and resistant to the disease. Relying on these imaging findings, we then profiled gene expression levels from postmortem brainstem regions, identifying a...
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