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Polyglutamine (PolyQ) Diseases: Navigating the Landscape of Neurodegeneration

12 Jul 2024

Abstract excerpt

Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with abnormally expanded polyglutamine tract. A total of nine polyQ disorders have been identified, including Huntington's disease, six spinocerebellar ataxias, dentatorubral pallidoluysian atrophy (DRPLA), and spinal and bulbar muscular atrophy (SBMA)....

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PMID: 38996083
DOI: 10.1021/acschemneuro.4c00184

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