Article

Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinson's Disease

2025-05-15

Abstract excerpt

<title>Abstract</title> Parkinson’s Disease (PD) is a prevalent neurodegenerative disorder characterized by the accumulation and aggregation of α-synuclein as a defining pathological hallmark. Misfolding and aggregation of α-synuclein disrupt cellular homeostasis, hinder mitochondrial function, and activate neuroinflammatory responses, ultimately resulting in neuronal death. Recent biomarker studies have repor...

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Literature Corpus work: bd735248-31d3-5ab8-8cb2-68b509d21786
DOI: 10.21203/rs.3.rs-6648986/v1

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