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Article

M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus.

mBio - 31 Aug 2010

Cole Jason N, Pence Morgan A, von Köckritz-Blickwede Maren, Hollands Andrew, Gallo Richard L, Walker Mark J, Nizet Victor

Abstract excerpt

The initiation of hyperinvasive disease in group A Streptococcus (GAS) serotype M1T1 occurs by mutation within the covRS two-component regulon (named covRS for control of virulence regulatory sensor kinase), which promotes resistance to neutrophil-mediated killing through the upregulation of bacteriophage-encoded Sda1 DNase. To determine whether other virulence factors contribute to this phase-switching...

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Source

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Identifiers

PMID: 20827373
DOI: 10.1128/mBio.00191-10
PMCID: PMC2934611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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