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Article

Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage.

mBio - 5 Feb 2025

Richter Johanna, Cork Amanda J, Ong Yvette, Keller Nadia, Hayes Andrew J, Schembri Mark A, Jennison Amy V, Davies Mark R, Schroder Kate, Walker Mark J, Brouwer Stephan

Abstract excerpt

Group A Streptococcus (GAS) is a human-adapted pathogen responsible for a variety of diseases. The GAS M1UK lineage has contributed significantly to the recently reported increases in scarlet fever and invasive infections. However, the basis for its evolutionary success is not yet fully understood. During the transition to systemic disease, the M1 serotype is known to give rise to spontaneous mutations in the...

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PMID: 39688411
DOI: 10.1128/mbio.03366-24
PMCID: PMC11796353

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