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Article

Neutrophils select hypervirulent CovRS mutants of M1T1 group A Streptococcus during subcutaneous infection of mice.

Infection and immunity - 1 Apr 2014

Li Jinquan, Liu Guanghui, Feng Wenchao, Zhou Yang, Liu Mengyao, Wiley James A, Lei Benfang

Abstract excerpt

Pathogen mutants arise during infections. Mechanisms of selection for pathogen variants are poorly understood. We tested whether neutrophils select mutations in the two-component regulatory system CovRS of group A Streptococcus (GAS) during infection using the lack of production of the protease SpeB (SpeB activity negative [SpeB(A-)]) as a marker. Depletion of neutrophils by antibodies RB6-8C5 and 1A8 reduced the...

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Identifiers

PMID: 24452689
DOI: 10.1128/IAI.01458-13
PMCID: PMC3993395

Genes

CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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