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Article

Streptococcal inhibitor of complement promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus.

Journal of innate immunity - 1 Jan 2010

Pence Morgan A, Rooijakkers Suzan H M, Cogen Anna L, Cole Jason N, Hollands Andrew, Gallo Richard L, Nizet Victor

Abstract excerpt

Streptococcal inhibitor of complement (SIC) is a highly polymorphic extracellular protein and putative virulence factor secreted by M1 and M57 strains of group A Streptococcus (GAS). The sic gene is highly upregulated in invasive M1T1 GAS isolates following selection of mutations in the covR/S regulatory locus in vivo. Previous work has shown that SIC (allelic form 1.01) binds to and inactivates complement C5b67...

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Identifiers

PMID: 20814187
DOI: 10.1159/000317672
PMCID: PMC3219503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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