Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parameters governing invasive disease propensity of non-M1 serotype group A streptococci.

Journal of innate immunity - 1 Jan 2010

Maamary Peter G, Sanderson-Smith Martina L, Aziz Ramy K, Hollands Andrew, Cole Jason N, McKay Fiona C, McArthur Jason D, Kirk Joshua K, Cork Amanda J, Keefe Rachael J, Kansal Rita G, Sun Hongmin, Taylor William L, Chhatwal Gursharan S, Ginsburg David, Nizet Victor, Kotb Malak, Walker Mark J

Abstract excerpt

Group A Streptococcus (GAS) causes rare but life-threatening syndromes of necrotizing fasciitis and toxic shock-like syndrome in humans. The GAS serotype M1T1 clone has globally disseminated, and mutations in the control of virulence regulatory sensor kinase (covRS) operon correlate with severe invasive disease. Here, a cohort of non-M1 GAS was screened to determine whether mutation in covRS triggers systemic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Complementation Test
Share to Histidine Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Evasion

Share to Intracellular Signaling Peptides and Proteins

Share to Microarray Analysis

Share to Neutrophils

Share to Streptococcal Infections

Share to Streptococcus pyogenes

Source

Open in PubMed Open full text

Identifiers

PMID: 20814186
DOI: 10.1159/000317640
PMCID: PMC3219504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parameters governing invasive disease propensity of non-M1 serotype group A streptococci.PMID 20814186Read ↗

M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus.Semantic proximity Read ↗

DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection.Semantic proximity Read ↗

Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage.Semantic proximity Read ↗

Serotype M3 and M28 Group A Streptococci Have Distinct Capacities to Evade Neutrophil and TNF-α Responses and to Invade Soft Tissues.Semantic proximity Read ↗

Dissection of the molecular basis for hypervirulence of an in vivo-selected phenotype of the widely disseminated M1T1 strain of group A Streptococcus bacteria.Semantic proximity Read ↗

Tracing the recent evolution of Group A Streptococcus M1 serotype.Semantic proximity Read ↗

Understanding the determinants of pathogenicity in Group A streptococcusSemantic proximity Read ↗

Characterization of Streptococcus pyogenes isolates from French children: emm-1 genotype is associated with invasive infections and spread of the M1UK clone.Semantic proximity Read ↗

A molecular trigger for intercontinental epidemics of group A StreptococcusSemantic proximity Read ↗

Highly virulent M1 Streptococcus pyogenes isolates resistant to clindamycin.Semantic proximity Read ↗

New understandings in Streptococcus pyogenesSemantic proximity Read ↗

Coiled-coil irregularities of the M1 protein structure promote M1–fibrinogen interaction and influence group A Streptococcus host cell interactions and virulenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.