Article
Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface.
PloS one - 1 Jan 2018
Galloway-Peña Jessica, DebRoy Sruti, Brumlow Chelcy, Li Xiqi, Tran Truc T, Horstmann Nicola, Yao Hui, Chen Ken, Wang Fang, Pan Bih-Fang, Hawke David H, Thompson Erika J, Arias Cesar A, Fowler Vance G, Bhatti Micah M, Kalia Awdhesh, Flores Anthony R, Shelburne Samuel A
Abstract excerpt
Inactivating mutations in the control of virulence two-component regulatory system (covRS) often account for the hypervirulent phenotype in severe, invasive group A streptococcal (GAS) infections. As CovR represses production of the anti-phagocytic hyaluronic acid capsule, high level capsule production is generally considered critical to the hypervirulent phenotype induced by CovRS inactivation. There have...
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