Article
Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones
21 Feb 2017
Abstract excerpt
Histones are essential elements of chromatin structure and gene regulation in eukaryotes. An unexpected attribute of these nuclear proteins is their antimicrobial activity. A framework for histone release and function in host defense in vivo was revealed with the discovery of neutrophil extracellular traps, a specialized cell death process in which DNA-based structures containing histones are extruded to ensnare...
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