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Article

DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection.

Nature medicine - 1 Aug 2007

Walker Mark J, Hollands Andrew, Sanderson-Smith Martina L, Cole Jason N, Kirk Joshua K, Henningham Anna, McArthur Jason D, Dinkla Katrin, Aziz Ramy K, Kansal Rita G, Simpson Amelia J, Buchanan John T, Chhatwal Gursharan S, Kotb Malak, Nizet Victor

Abstract excerpt

Most invasive bacterial infections are caused by species that more commonly colonize the human host with minimal symptoms. Although phenotypic or genetic correlates underlying a bacterium's shift to enhanced virulence have been studied, the in vivo selection pressures governing such shifts are poorly understood. The globally disseminated M1T1 clone of group A Streptococcus (GAS) is linked with the rare but...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17632528
DOI: 10.1038/nm1612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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