Article
Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2013
Tsatsaronis James A, Hollands Andrew, Cole Jason N, Maamary Peter G, Gillen Christine M, Ben Zakour Nouri L, Kotb Malak, Nizet Victor, Beatson Scott A, Walker Mark J, Sanderson-Smith Martina L
Abstract excerpt
In Western countries, invasive infections caused by M1T1 serotype group A Streptococcus (GAS) are epidemiologically linked to mutations in the control of virulence regulatory 2-component operon (covRS). In indigenous communities and developing countries, severe GAS disease is associated with genetically diverse non-M1T1 GAS serotypes. Hypervirulent M1T1 covRS mutant strains arise through selection by human...
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