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Article

Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains.

The Journal of biological chemistry - 5 Nov 2010

Kashlan Ossama B, Boyd Cary R, Argyropoulos Christos, Okumura Sora, Hughey Rebecca P, Grabe Michael, Kleyman Thomas R

Abstract excerpt

The epithelial Na(+) channel (ENaC) mediates the rate-limiting step in transepithelial Na(+) transport in the distal segments of the nephron and in the lung. ENaC subunits are cleaved by proteases, resulting in channel activation due to the release of inhibitory tracts. Peptides derived from these tracts inhibit channel activity. The mechanism by which these intrinsic inhibitory tracts reduce channel activity is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20817728
DOI: 10.1074/jbc.M110.167064
PMCID: PMC2966135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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