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Article

Acute downregulation of ENaC by EGF involves the PY motif and putative ERK phosphorylation site.

The Journal of general physiology - 1 Sept 2007

Falin Rebecca A, Cotton Calvin U

Abstract excerpt

The epithelial sodium channel (ENaC) is expressed in a variety of tissues, including the renal collecting duct, where it constitutes the rate-limiting step for sodium reabsorption. Liddle's syndrome is caused by gain-of-function mutations in the beta and gamma subunits of ENaC, resulting in enhanced Na reabsorption and hypertension. Epidermal growth factor (EGF) causes acute inhibition of Na absorption in...

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Source

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Identifiers

PMID: 17724164
DOI: 10.1085/jgp.200709775
PMCID: PMC2151644

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acute downregulation of ENaC by EGF involves the PY motif and putative ERK phosphorylation site.PMID 17724164Read ↗

Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin.Semantic proximity Read ↗

The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool.Semantic proximity Read ↗

Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.Semantic proximity Read ↗

Influence of proteolytic cleavage of ENaC's γ subunit upon Na+ and K+ handling.Semantic proximity Read ↗

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.Semantic proximity Read ↗

Liddle-Mutation of the β-Subunit, but not the γ-Subunit, Attenuates Protein Kinase C-Mediated Inhibition of Human Epithelial Sodium Channels (hENaC).Semantic proximity Read ↗

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.Semantic proximity Read ↗

Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition.Semantic proximity Read ↗

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.Semantic proximity Read ↗

Overexpression of the epithelial Na+ channel gamma subunit in collecting duct cells: interactions of Liddle's mutations and steroids on expression and function.Semantic proximity Read ↗

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