Article
Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain.
The Journal of biological chemistry - 9 Oct 2015
Chen Jingxin, Ray Evan C, Yates Megan E, Buck Teresa M, Brodsky Jeffrey L, Kinlough Carol L, Winarski Katie L, Hughey Rebecca P, Kleyman Thomas R, Sheng Shaohu
Abstract excerpt
The extracellular regions of epithelial Na(+) channel subunits are highly ordered structures composed of domains formed by α helices and β strands. Deletion of the peripheral knuckle domain of the α subunit in the αβγ trimer results in channel activation, reflecting an increase in channel open probability due to a loss of the inhibitory effect of external Na(+) (Na(+) self-inhibition). In contrast, deletion of...
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