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Article

Influence of proteolytic cleavage of ENaC's γ subunit upon Na+ and K+ handling.

American journal of physiology. Renal physiology - 1 Jun 2024

Ray Evan C, Nickerson Andrew, Sheng Shaohu, Carrisoza-Gaytan Rolando, Lam Tracey, Marciszyn Allison, Zhang Lei, Jordahl Alexa, Bi Chunming, Winfrey Aaliyah, Kou Zhaohui, Gingras Sebastien, Kirabo Annet, Satlin Lisa M, Kleyman Thomas R

Abstract excerpt

The epithelial Na+ channel (ENaC) γ subunit is essential for homeostasis of Na+, K+, and body fluid. Dual γ subunit cleavage before and after a short inhibitory tract allows dissociation of this tract, increasing channel open probability (PO), in vitro. Cleavage proximal to the tract occurs at a furin recognition sequence (143RKRR146, in the mouse γ subunit). Loss of furin-mediated cleavage prevents in vitro...

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Identifiers

PMID: 38634134
DOI: 10.1152/ajprenal.00027.2024
PMCID: PMC11381034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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