Article
The N-terminal domain allosterically regulates cleavage and activation of the epithelial sodium channel.
The Journal of biological chemistry - 15 Aug 2014
Kota Pradeep, Buchner Ginka, Chakraborty Hirak, Dang Yan L, He Hong, Garcia Guilherme J M, Kubelka Jan, Gentzsch Martina, Stutts M Jackson, Dokholyan Nikolay V
Abstract excerpt
The epithelial sodium channel (ENaC) is activated upon endoproteolytic cleavage of specific segments in the extracellular domains of the α- and γ-subunits. Cleavage is accomplished by intracellular proteases prior to membrane insertion and by surface-expressed or extracellular soluble proteases once ENaC resides at the cell surface. These cleavage events are partially regulated by intracellular signaling through...
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