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Article

Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases.

The Journal of biological chemistry - 7 Jan 2011

Kashlan Ossama B, Adelman Joshua L, Okumura Sora, Blobner Brandon M, Zuzek Zachary, Hughey Rebecca P, Kleyman Thomas R, Grabe Michael

Abstract excerpt

The epithelial Na(+) channel (ENaC) mediates Na(+) transport across high resistance epithelia. This channel is assembled from three homologous subunits with the majority of the protein's mass found in the extracellular domains. Acid-sensing ion channel 1 (ASIC1) is homologous to ENaC, but a key f...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20974852
DOI: 10.1074/jbc.M110.167098
PMCID: PMC3013024

Genes

ASIC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20974852-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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