Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel determinants of epithelial sodium channel gating within extracellular thumb domains.

The Journal of biological chemistry - 20 Mar 2009

Maarouf Ahmad B, Sheng Nan, Chen Jingxin, Winarski Katie L, Okumura Sora, Carattino Marcelo D, Boyd Cary R, Kleyman Thomas R, Sheng Shaohu

Abstract excerpt

Activity of the epithelial Na(+) channel (ENaC) is modulated by Na(+) self-inhibition, an allosteric down-regulation of channel open probability by extracellular Na(+). We searched for determinants of Na(+) self-inhibition by analyzing changes in this inhibitory response resulting from specific mutations within the extracellular domains of mouse ENaC subunits. Mutations at gammaMet(438) altered the Na(+)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial Sodium Channels
Share to Ion Channel Gating

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ion Transport

Share to Oocytes

Share to Protein Structure, Secondary

Share to Protein Subunits

Share to Sodium

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 19158091
DOI: 10.1074/jbc.M807060200
PMCID: PMC2658069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel determinants of epithelial sodium channel gating within extracellular thumb domains.PMID 19158091Read ↗

Extracellular histidine residues crucial for Na+ self-inhibition of epithelial Na+ channels.Semantic proximity Read ↗

Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain.Semantic proximity Read ↗

Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block.Semantic proximity Read ↗

Asymmetric organization of the pore region of the epithelial sodium channel.Semantic proximity Read ↗

Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels.Semantic proximity Read ↗

The epithelial sodium channel (ENaC): new insights into ENaC gating.Semantic proximity Read ↗

Open probability of the epithelial sodium channel is regulated by intracellular sodium.Semantic proximity Read ↗

Varying selection pressure for a Na <sup>+</sup> sensing site in epithelial Na <sup>+</sup> channel subunits reflect divergent roles in Na <sup>+</sup> homeostasisSemantic proximity Read ↗

Extracellular protons regulate human ENaC by modulating Na+ self-inhibition.Semantic proximity Read ↗

Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system.Semantic proximity Read ↗

A Missense Mutation in the Extracellular Domain of αENaC Causes Liddle SyndromeSemantic proximity Read ↗

Identification of extracellular domain residues required for epithelial Na+ channel activation by acidic pH.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.