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Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection

10 Apr 2017

Abstract excerpt

Cell surface aminopeptidase N (APN) is a membrane-bound ectoenzyme that hydrolyzes proteins and peptides and regulates numerous cell functions. APN participates in tumor cell expansion and motility, and is a target for cancer therapies. Small drugs that bind to the APN active site inhibit catalysis and suppress tumor growth. APN is also a major cell entry receptor for coronavirus, which binds to a region distant...

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PMID: 28393915
DOI: 10.1038/srep46045

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