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Article

Base of the thumb domain modulates epithelial sodium channel gating.

The Journal of biological chemistry - 29 Apr 2011

Shi Shujie, Ghosh D Dipon, Okumura Sora, Carattino Marcelo D, Kashlan Ossama B, Sheng Shaohu, Kleyman Thomas R

Abstract excerpt

The activity of the epithelial sodium channel (ENaC) is modulated by multiple external factors, including proteases, cations, anions and shear stress. The resolved crystal structure of acid-sensing ion channel 1 (ASIC1), a structurally related ion channel, and mutagenesis studies suggest that the large extracellular region is involved in recognizing external signals that regulate channel gating. The thumb domain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21367859
DOI: 10.1074/jbc.M110.191734
PMCID: PMC3083234

Genes

ASIC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Base of the thumb domain modulates epithelial sodium channel gating.PMID 21367859Read ↗

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