Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

When Cre-mediated recombination in mice does not result in protein loss.

Genetics - 1 Nov 2010

Turlo Kirsten A, Gallaher Sean D, Vora Roshni, Laski Frank A, Iruela-Arispe M Luisa

Abstract excerpt

Cre/loxP recombination enables cellular specificity and, in the case of inducible systems, temporal control of genomic deletions. Here we used a SM22α tamoxifen-inducible Cre line to inactivate β1 integrin in adult smooth muscle. Interestingly, analysis of two distinct β1 loxP transgenic mice revealed vastly different outcomes after β1 integrin deletion. Lethality occurred 4 weeks postinduction in one Cre/loxP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Mammalian
Share to Fibroblasts
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrases

Share to Integrin beta1

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20813881
DOI: 10.1534/genetics.110.121608
PMCID: PMC2975293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

When Cre-mediated recombination in mice does not result in protein loss.PMID 20813881Read ↗

Site- and time-specific gene targeting in the mouse.Semantic proximity Read ↗

Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping.Semantic proximity Read ↗

Sustained somatic gene inactivation by viral transfer of Cre recombinase.Semantic proximity Read ↗

A rapid strategy to detect the recombined allele in LSL-TβRICA transgenic mice.Semantic proximity Read ↗

Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouseSemantic proximity Read ↗

Unspecific DNA recombination in AdipoqCre-ERT2 - mediated knockout approaches in transgenic mice is sex-, age- and genotype-dependent.Semantic proximity Read ↗

Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.Semantic proximity Read ↗

Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion.Semantic proximity Read ↗

Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult MiceSemantic proximity Read ↗

Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles.Semantic proximity Read ↗

In vivo expression of a conditional TGF-beta1 transgene: no evidence for TGF-beta1 transgene expression in SM22alpha-tTA transgenic mice.Semantic proximity Read ↗

Tamoxifen administration in pregnant mice can be deleterious to both mother and embryoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.