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Article

Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2016

Levit-Zerdoun Ella, Becker Martin, Pohlmeyer Roland, Wilhelm Isabel, Maity Palash Chandra, Rajewsky Klaus, Reth Michael, Hobeika Elias

Abstract excerpt

Expression of a functional BCR is essential for the development of mature B cells and has been invoked in the control of their maintenance. To test this maintenance function in a new experimental setting, we used the tamoxifen-inducible mb1-CreER(T2) mouse strain to delete or truncate either the mb-1 gene encoding the BCR signaling subunit Igα or the VDJ segment of the IgH (H chain [HC]). In this system,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26843325
DOI: 10.4049/jimmunol.1501707

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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