Article
Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles.
Physiological genomics - 17 Sept 2008
de Lange Willem J, Halabi Carmen M, Beyer Andreas M, Sigmund Curt D
Abstract excerpt
Tissue-specific knockouts generated through Cre-loxP recombination have become an important tool to manipulate the mouse genome. Normally, two successive rounds of breeding are performed to generate mice carrying two floxed target-gene alleles and a transgene expressing Cre-recombinase tissue-specifically. We show herein that two promoters commonly used to generate endothelium-specific (Tie2) and smooth...
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