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Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo

27 Jun 2019

Abstract excerpt

Since it was introduced 20 years ago, tamoxifen-inducible genetic recombination in vivo has become a standard tool in many fields. This technique has great utility, allowing precise temporal and spatial gene recombination mediated by expression of a Cre recombinase-oestrogen receptor hormone binding domain fusion protein. It is frequently used in developmental biology, either for accurate spatio-temporal gene...

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PMID: 31248325
DOI: 10.1177/0023677219856918

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