Article
Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion.
Developmental biology - 1 May 1996
Gardner H, Kreidberg J, Koteliansky V, Jaenisch R
Abstract excerpt
Integrin alpha 1 is a receptor for laminin and collagen which is expressed widely and dynamically in embryogenesis and has been implicated in various developmental processes including establishment of the placenta and formation of the central and peripheral nervous system. In the adult it is the...
Topics
- Alleles
- Animals
- Antigens, CD
- Base Sequence
- Cell Adhesion
- Cell Movement
- Cells, Cultured
- Chimera
- Collagen
- Embryonic and Fetal Development
- Female
- Fertility
- Fibroblasts
- Gene Deletion
- Gene Targeting
- Integrin alpha1
- Integrins
- Laminin