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Article

Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse

1 Jul 2004

Abstract excerpt

Abstract To generate temporally controlled targeted somatic mutations selectively and efficiently in hepatocytes, we established SA +/CreERT2 mice in which the tamoxifen‐dependent Cre‐ER T2 recombinase coding sequence preceded by an internal ribosomal entry site was inserted in the 3′ untranslated region of the serum albumin (SA) gene. Whereas the wildtype SA allele was strongly expressed in the liver and at...

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PMID: 15282742
DOI: 10.1002/gene.20039

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