Article
Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2005
Canzian Federico, McKay James D, Cleveland Rebecca J, Dossus Laure, Biessy Carine, Boillot Catherine, Rinaldi Sabina, Llewellyn Midge, Chajès Véronique, Clavel-Chapelon Françoise, Téhard Bertrand, Chang-Claude Jenny, Linseisen Jakob, Lahmann Petra H, Pischon Tobias, Trichopoulos Dimitrios, Trichopoulou Antonia, Zilis Dimosthenes, Palli Domenico, Tumino Rosario, Vineis Paolo, Berrino Franco, Bueno-de-Mesquita H Bas, van Gils Carla H, Peeters Petra H M, Pera Guillem, Barricarte Aurelio, Chirlaque María-Dolores, Quirós J Ramon, Larrañaga Nerea, Martínez-García Carmen, Allen Naomi E, Key Timothy J, Bingham Sheila A, Khaw Kay-Tee, Slimani Nadia, Norat Teresa, Riboli Elio, Kaaks Rudolf
Abstract excerpt
Insulin-like growth factor-I (IGF-I) stimulates cell proliferation and can enhance the development of tumors in different organs. Epidemiologic studies have shown that an elevated level of circulating IGF-I is associated to increased risk of breast cancer as well as other cancers. Genetic variant...
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