Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomewide meta‐analysis identifies loci associated with <scp>IGF</scp> ‐I and <scp>IGFBP</scp> ‐3 levels with impact on age‐related traits

21 Jun 2016

Abstract excerpt

The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30 884 adults of European ancestry from 21 studies, we confirmed and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Syndromes and Imprinting
Share to Growth Hormone and Insulin-like Growth Factors
Share to Lipid metabolism and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27329260
DOI: 10.1111/acel.12490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomewide meta‐analysis identifies loci associated with <scp>IGF</scp> ‐I and <scp>IGFBP</scp> ‐3 levels with impact on age‐related traitsPMID 27329260Read ↗

A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.Semantic proximity Read ↗

Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.Semantic proximity Read ↗

FOXO3A genotype is strongly associated with human longevity.Semantic proximity Read ↗

IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer.Semantic proximity Read ↗

Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms.Semantic proximity Read ↗

IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).Semantic proximity Read ↗

Genetic and dietary determinants of insulin-like growth factor (IGF)-1 and IGF binding protein (BP)-3 levels among Chinese women.Semantic proximity Read ↗

Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians.Semantic proximity Read ↗

Characterizing short stature by insulin-like growth factor axis status and genetic associations: results from the prospective, cross-sectional, epidemiogenetic EPIGROW study.Semantic proximity Read ↗

Unraveling Insulin-Like Growth Factor Binding Protein-3 Actions in Human DiseaseSemantic proximity Read ↗

Associations of insulin-like growth factor binding protein-3 gene polymorphisms with IGF-I activity and lipid parameters in adolescents.Semantic proximity Read ↗

Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.