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IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer.

Human molecular genetics - 1 Jan 2006

Al-Zahrani Ali, Sandhu Manjinder S, Luben Robert N, Thompson Deborah, Baynes Caroline, Pooley Karen A, Luccarini Craig, Munday Hannah, Perkins Barbara, Smith Paula, Pharoah Paul D P, Wareham Nicholas J, Easton Douglas F, Ponder Bruce A J, Dunning Alison M

Abstract excerpt

Experimental and observational studies in humans and animals suggest that insulin-like growth factor 1 (IGF1) and its principal binding protein, IGFBP3, may influence breast cancer susceptibility. We have examined the association of nine and four single nucleotide polymorphisms (SNPs) in the IGF1 gene and in the IGFBP3 genes, respectively, with circulating levels of their gene products in a population-based study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16306136
DOI: 10.1093/hmg/ddi398

Genes

IGF1
IGFBP3

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