Article
Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population.
The Journal of clinical endocrinology and metabolism - 1 Sept 2007
Cheng Iona, DeLellis Henderson Katherine, Haiman Christopher A, Kolonel Laurence N, Henderson Brian E, Freedman Matthew L, Le Marchand Loïc
Abstract excerpt
CONTEXT: Both circulating levels and genetic variation of IGFs have been associated with cancer risk, yet the relationship between the two is not well understood. OBJECTIVE: To investigate whether common genetic variation in IGF1, IGF binding protein 1 (IGFBP1), and IGFBP3 influences circulating levels of IGF-I, IGFBP-1, and IGFBP-3, we conducted a cross-sectional study of African-American, Native Hawaiian,...
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