A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.

doi:10.1093/hmg/ddq560

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Article

A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.

Human molecular genetics - 15 Mar 2011

Kaplan Robert C, Petersen Ann-Kristin, Chen Ming-Huei, Teumer Alexander, Glazer Nicole L, Döring Angela, Lam Carolyn S P, Friedrich Nele, Newman Anne, Müller Martina, Yang Qiong, Homuth Georg, Cappola Anne, Klopp Norman, Smith Holly, Ernst Florian, Psaty Bruce M, Wichmann H-Erich, Sawyer Douglas B, Biffar Reiner, Rotter Jerome I, Gieger Christian, Sullivan Lisa S, Völzke Henry, Rice Kenneth, Spyroglou Ariadni, Kroemer Heyo K, Ida Chen Y-D, Manolopoulou Jenny, Nauck Matthias, Strickler Howard D, Goodarzi Mark O, Reincke Martin, Pollak Michael N, Bidlingmaier Martin, Vasan Ramachandran S, Wallaschofski Henri

Abstract excerpt

Insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-3 (IGFBP-3) are involved in cell replication, proliferation, differentiation, protein synthesis, carbohydrate homeostasis and bone metabolism. Circulating IGF-I and IGFBP-3 concentrations predict anthropometric traits and risk of cancer and cardiovascular disease. In a genome-wide association study of 10 280 middle-aged and older...

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Identifiers

PMID: 21216879
DOI: 10.1093/hmg/ddq560
PMCID: PMC3043664

Genes

IGFBP3
FOXO3
IGFALS
SORCS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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