Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection.

doi:10.1084/jem.20090378

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Article

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection.

The Journal of experimental medicine - 8 Jun 2009

Salazar-Gonzalez Jesus F, Salazar Maria G, Keele Brandon F, Learn Gerald H, Giorgi Elena E, Li Hui, Decker Julie M, Wang Shuyi, Baalwa Joshua, Kraus Matthias H, Parrish Nicholas F, Shaw Katharina S, Guffey M Brad, Bar Katharine J, Davis Katie L, Ochsenbauer-Jambor Christina, Kappes John C, Saag Michael S, Cohen Myron S, Mulenga Joseph, Derdeyn Cynthia A, Allen Susan, Hunter Eric, Markowitz Martin, Hraber Peter, Perelson Alan S, Bhattacharya Tanmoy, Haynes Barton F, Korber Bette T, Hahn Beatrice H, Shaw George M

Abstract excerpt

Identification of full-length transmitted HIV-1 genomes could be instrumental in HIV-1 pathogenesis, microbicide, and vaccine research by enabling the direct analysis of those viruses actually responsible for productive clinical infection. We show in 12 acutely infected subjects (9 clade B and 3 clade C) that complete HIV-1 genomes of transmitted/founder viruses can be inferred by single genome amplification and...

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PMID: 19487424
DOI: 10.1084/jem.20090378
PMCID: PMC2715054

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CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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