Article
Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection.
PLoS pathogens - 1 Jan 2012
Henn Matthew R, Boutwell Christian L, Charlebois Patrick, Lennon Niall J, Power Karen A, Macalalad Alexander R, Berlin Aaron M, Malboeuf Christine M, Ryan Elizabeth M, Gnerre Sante, Zody Michael C, Erlich Rachel L, Green Lisa M, Berical Andrew, Wang Yaoyu, Casali Monica, Streeck Hendrik, Bloom Allyson K, Dudek Tim, Tully Damien, Newman Ruchi, Axten Karen L, Gladden Adrianne D, Battis Laura, Kemper Michael, Zeng Qiandong, Shea Terrance P, Gujja Sharvari, Zedlack Carmen, Gasser Olivier, Brander Christian, Hess Christoph, Günthard Huldrych F, Brumme Zabrina L, Brumme Chanson J, Bazner Suzane, Rychert Jenna, Tinsley Jake P, Mayer Ken H, Rosenberg Eric, Pereyra Florencia, Levin Joshua Z, Young Sarah K, Jessen Heiko, Altfeld Marcus, Birren Bruce W, Walker Bruce D, Allen Todd M
Abstract excerpt
Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolving viral quasispecies. Here, we report on a high-throughput whole HIV-1 genome deep sequencing platform that combines 454 pyrosequencing with novel assembly and variant detection algorithms. In one subject we combined...
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