Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

doi:10.1093/hmg/ddl438

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Article

Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

Human molecular genetics - 1 Jan 2007

Saccone Scott F, Hinrichs Anthony L, Saccone Nancy L, Chase Gary A, Konvicka Karel, Madden Pamela A F, Breslau Naomi, Johnson Eric O, Hatsukami Dorothy, Pomerleau Ovide, Swan Gary E, Goate Alison M, Rutter Joni, Bertelsen Sarah, Fox Louis, Fugman Douglas, Martin Nicholas G, Montgomery Grant W, Wang Jen C, Ballinger Dennis G, Rice John P, Bierut Laura Jean

Abstract excerpt

Nicotine dependence is one of the world's leading causes of preventable death. To discover genetic variants that influence risk for nicotine dependence, we targeted over 300 candidate genes and analyzed 3713 single nucleotide polymorphisms (SNPs) in 1050 cases and 879 controls. The Fagerström test for nicotine dependence (FTND) was used to assess dependence, in which cases were required to have an FTND of 4 or...

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Identifiers

PMID: 17135278
DOI: 10.1093/hmg/ddl438
PMCID: PMC2270437

Genes

CHRNA5
CHRNB3
GABRA4
KCNJ6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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