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Article

Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2016

Zuo Lingjun, Tan Yunlong, Li Chiang-Shan R, Wang Zhiren, Wang Kesheng, Zhang Xiangyang, Lin Xiandong, Chen Xiangning, Zhong Chunlong, Wang Xiaoping, Wang Jijun, Lu Lu, Luo Xingguang

Abstract excerpt

Nicotine's rewarding effects are mediated through distinct subunits of nAChRs, encoded by different nicotinic cholinergic receptor (CHRN) genes and expressed in discrete regions in the brain. In the present study, we aimed to test the associations between rare variants at CHRN genes and nicotine dependence (ND), and alcohol dependence (AD). A total of 26,498 subjects with nine different neuropsychiatric disorders...

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Identifiers

PMID: 27473937
DOI: 10.1002/ajmg.b.32476
PMCID: PMC5587505

Genes

CHRNB1
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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