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Article

The contribution of rare and common variants in 30 genes to risk nicotine dependence.

Molecular psychiatry - 1 Nov 2015

Yang J, Wang S, Yang Z, Hodgkinson C A, Iarikova P, Ma J Z, Payne T J, Goldman D, Li M D

Abstract excerpt

Genetic and functional studies have revealed that both common and rare variants of several nicotinic acetylcholine receptor subunits are associated with nicotine dependence (ND). In this study, we identified variants in 30 candidate genes including nicotinic receptors in 200 sib pairs selected from the Mid-South Tobacco Family population with equal numbers of African Americans (AAs) and European Americans (EAs)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25450229
DOI: 10.1038/mp.2014.156
PMCID: PMC4452458

Genes

CHRNA9
NRXN1
NRXN3
ARRB2
CDH13
CHRNA2
DBH
DNM1
DRD2
GABBR2
NRXN2
NTRK2

Variants

rs142807401
rs142807401
rs142807401
rs142807401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The contribution of rare and common variants in 30 genes to risk nicotine dependence.PMID 25450229Read ↗

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.Semantic proximity Read ↗

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Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Semantic proximity Read ↗

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Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans.Semantic proximity Read ↗

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Semantic proximity Read ↗

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rs142807401