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Article

Viral Delivery of Non-Mutated Human Truncated Tau to Neurons Recapitulates Key Features of Human Tauopathy in Wild-Type Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Vogels Thomas, Vargová Gréta, Brezováková Veronika, Quint Wim Hendricus, Hromádka Tomáš

Abstract excerpt

BACKGROUND: Neuronal accumulation of hyperphosphorylated and truncated tau aggregates is one of the major defining factors and key drivers of neurodegeneration in Alzheimer's disease and other tauopathies. OBJECTIVE: We developed an AAV-induced model of tauopathy mediated by human truncated tau protein without familial frontotemporal dementia-related mutations to study tau propagation and the functional...

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PMID: 32675411
DOI: 10.3233/JAD-200047

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