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Article

Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.

Behavioural brain research - 15 Jul 2012

Mustroph Martina L, King Michael A, Klein Ronald L, Ramirez Julio J

Abstract excerpt

Tauopathy in the hippocampus is one of the earliest cardinal features of Alzheimer's disease (AD), a condition characterized by progressive memory impairments. In fact, density of tau neurofibrillary tangles (NFTs) in the hippocampus strongly correlates with severity of cognitive impairments in AD. In the present study, we employed a somatic cell gene transfer technique to create a rodent model of tauopathy by...

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Identifiers

PMID: 22561128
DOI: 10.1016/j.bbr.2012.04.034
PMCID: PMC3378764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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