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Article

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model

4 Jul 2016

Abstract excerpt

A central question in Alzheimer's Disease (AD) is whether the neuritic plaque is necessary and sufficient for the development of tau pathology. Hyperphosphorylation of tau is found within dystrophic neurites surrounding β-amyloid deposits in AD mouse models but the pathological conversion of tau is absent. Likewise, expression of a human tau repeat domain in mice is insufficient to drive the pathological...

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PMID: 27373369
DOI: 10.1038/ncomms12082

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