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Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!

Cell cycle (Georgetown, Tex.) - 15 Aug 2010

Grzeschik Nicola A, Parsons Linda M, Richardson Helena E

Abstract excerpt

Loss of function of the neoplastic tumors suppressors, lgl, scrib and dlg or overexpression of the apical polarity components, Crumbs and atypical protein kinase C (aPKC), are associated with polarity loss and tissue overgrowth, however, the mechanism behind these effects is poorly understood. In our recent study, we showed that Lgl, aPKC and Crumbs mediate their effects on proliferation and survival via the...

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Identifiers

PMID: 20724829
DOI: 10.4161/cc.9.16.12633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!PMID 20724829Read ↗

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.Semantic proximity Read ↗

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Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer.Semantic proximity Read ↗

Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.Semantic proximity Read ↗

Unveiling the Tumor Suppressors: Insights from Drosophila.Semantic proximity Read ↗

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy.Semantic proximity Read ↗

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.Semantic proximity Read ↗

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