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Article

Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.

BMC biology - 24 Sept 2009

Leong Gregory R, Goulding Karen R, Amin Nancy, Richardson Helena E, Brumby Anthony M

Abstract excerpt

BACKGROUND: Metastatic neoplasias are characterized by excessive cell proliferation and disruptions to apico-basal cell polarity and tissue architecture. Understanding how alterations in cell polarity can impact upon tumour development is, therefore, a central issue in cancer biology. The Drosophila gene scribble (scrib) encodes a PDZ-domain scaffolding protein that regulates cell polarity and acts as a tumour...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19778415
DOI: 10.1186/1741-7007-7-62
PMCID: PMC2760524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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